Peter B Barker

R21CA/RR91798-03 (R33) (Barker, P.) - 7/1/04-12/31/05

NIH/NCI

Title: Proton MR Spectroscopic Imaging in Human Breast Cancer The goal of this project is to develop techniques for proton spectroscopy in the human breast for the diagnosis of breast cancer.

DAMD170110713 (Barker, P.) 7/1/01-7/31/06

Congressionally Directed Medical Research Program.

Title: Proton MR Spectroscopic Imaging in NF-1 The goals of this project are to (1) investigate brain metabolism in Neurofibromatosis Type-1 (2) to establish the relationship between metabolism and cognitive impairment, and (3) establish the role of MRSI in the diagnosis of brain lesions in patients with NF-1.

1P41 RR15241-01A1(van Zijl, P.C.M., PI TRD 2 Barker, P.) 07/01/01 - 6/30/06

NIH/NINDS

Title: Resource for Quantitative Functional MRI The major goal is to provide state-of-the-art MRI and MRS data acquisition and image processing technology and unique MR expertise to facilitate the biomedical research of NIH-funded neuroscientists at several institutions in Maryland and throughout the USA.

5R01AG20287(Early, C.J.) 4/1/02-3/31/06

NIH/NINDS

Title: Response to Iron Treatment for Restless Leg Syndrome

The goal of this project is to determine the efficacy  of intravenous iron as a treatment for restless leg syndrome, including the usuage of MRI to monitor brain iron levels pre- and post-treatment.

5R01EY001849-26 (Zee, D.) 9/30/02-9/29/07

NIH/NEI

Title: Oculomotor Disorders--Clinical and Experimental study.

The goal of this project is to learn about the mechanism a of normal eye movement control and human ocular motor disorders using magnetic resonance imaging.

2R01HL56882(Bottomley, P) 4/1/03-3/31/08

NIH

Title:  MR studies of Myocardial Creatine Kinase Metabolism.

Quantitative 1H MRS creatine imaging techniques will be developed and applied to image metabolic defects and assess metabolic viability in patients with myocardial infraction (MI) and hyper-enhancing MRI lesions at acute and chronic follow up.  The creatine Kinase flux will be measured in the normal resting and stressed human heart, and in MI patients dysfunction using newly developed FAST 31P MRS techniques.

R01ES010975(Guilarte, T) 12/1/01-11/31/06

NIH

Title:  Molecular & Behavioral Effects of Low Level Mn Exposure.

The goal of this project is to determine the behavioural and neurochemical changes associated with chronic low-level manganese exposure in non-human primates.

MH711500-01A1(Sacktor, N) 3/16/05-2/28/10

NIMH

Title:  Oxidative Stress Markers and HIV Dementia.

The major goal of this project is to define the association between markers of oxidative stress and HIV dementia and to determine whether markers of oxidative stress predict either  the reversibility or progression of HIV dementia.

R01CA100184(Jacobs, MA) 07/1/04-6/30/08

NIH NIC

Title:  Multiparametric MRI in Breast Cancer.

The major goal of this project is to define investigate the diagnostic utility of multi-modality MR imaging and spectroscopy in breast cancer.

5R01NS042857 (Early, C.J.) 12/1/99-8/31/07

NIH/NINDS

Title: Dopamine Function in Restless Leg Syndrome

The major goal of this project is to use PET and MRI to understand the physiological basisof  restless leg syndrome.

5R01NS31238(Baumgartner, W.)12/1/04-11/30/07

NIH/NINDS

Title: Excitotoxicity in Circulatory Arrest - Brain Injury

The goal of this project is to improve the understanding of metabolic changes in the brain during hypothermic circulatory arrest (cardiac surgery), and to develop neuroprotective strategies and monitoring techniques.

R01DC5375(Hillis, A.)4/1/02-6/30/07

NIH/NIDCD

Title: Neural Basis for Lexical Processes in Hyperacute Stroke.

The major goals of this project are to identify the neural substrates of lexical and semantic representations of nouns and verbs, by correlating specific language impairments in huperacute stroke patients of brain dysfubction and damage identified by diffusion weighted imaging and perfusion weighted imaging.

R01NS047691-01A1(Hillis, A.)7/1/04-6/30/08

NINDS

Title: Neural Basis of Unilateral Spatial Neglect.

The main goal of this project is to improve the understanding of the neural basis of neglect by the use of diffusion and perfusion magnetic resonance imaging in acute stroke patients.

1R01NS42851-01A2(Horska, A.) 09/30/03-06/30/07

NIH

Title: Metabolic Effects of Brain Radiation in Children.

The goal of the study is to evaluate the effects of radiation on the brain metabolism, water diffusion, and lobar brain volumes in children receiving radiation therapy for brain tumors and ALL.