To test the hypothesis that novel magnetic resonance imaging (MRI) measures of regional brain structure and function, diffusion tensor imaging (DTI) and arterial spin labeling (ASL), will be reliable and valid measures of clinical status in subjects with

Grant: The Fidelity Foundations

PI Name: Dr. Marilyn Albert

PI Email: malbert9@jhmi.edu

PI Title: Director of the Division of Cognitive Neuroscience in the Dept of Neurology at Johns Hopkins Univ School of Medicine and Co-Director of the Johns Hopkins Alzheimer’s Disease Research Center.

Project Title: MRI Studies of Medial Temporal Lobe Function.

This study uses structural and functional magnetic resonance imaging (MRI) to examine the structure and function of brain regions critical for normal memory. The goal of this study is develop memory tasks that will selectively activate subregions of the anterior temporal lobe. Participants in the study will be young controls. The ultimate aim, however, is to develop memory tasks that can be used for the early identification of patients with Alzheimer’s disease. The Principal Investigator (PI) is Dr. Marilyn Albert, and the Co-PI is Dr. John Desmond.

Project Start: 01-SEPT-2004

Project End: 30-AUG-2005