Grant: GlaxoSmithKline

PI Name: Lyketsos,, Constantine

PI Email: kostas@jhmi.edu

PI Title: Clinical Core Leader, Alzheimer's Disease Research Center, JHU

Project Title: Reliability and Validity of DTI and ASL Measures in Mild Cognitive Impairment and Alzheimer’s Disease.

The goal of this study is obtain longitudinal data on the reliability of two novel imaging techniques and their relationship to clinical status in older persons with and without memory difficulty. The novel imaging methods are: diffusion tensor imaging (DTI) and arterial spin labeling (ASL). Standard imaging techniques, such as MPRAGE and Dual TSE will also be included. Three groups of subjects will be examined: (1) elderly normal controls (n=25), (2) subjects who meet criteria for mild cognitive impairment (n=25) and patients with mild Alzheimer’s disease (n=25) . Imaging and clinical data will be acquired every 3 months for 1 year. Blood will also be collected to evaluate biomarkers. If the DTI and ASL measures are reliable over time, they may be useful as a measure of drug efficacy in early phase clinical trials. The Principal Investigator (PI) is Dr. Constantine Lyketsos, and the Co-PI is Dr. Marilyn Albert.