Facilities: Bruker Biospec 11.7 T

Bruker Biospec 117/16 Ultra Shielded Refrigerated (USR) system is the first horizontal MRI system at 11.7 Tesla field strength. It delivers unsurpassed signal-to-noise ratio and resolution comparing to lower field small animal MRI systems. The bore size of the magnet is 155 mm, which provide easy access for imaging of rats and mouse. The drift rate for this magnet is 0.05 ppm/hr, and the homogeneity of the field is < 2 ppm for dsv 30 mm. The magnet is equipped with a two-stage Cryo-refrigerator (9 kW) which eliminates the need for liquid nitrogen and prolongs the liquid helium holding time. A Motorised Animal Positioning System is available on this scanner, designed to simplify animal handling and to increase animal throughput. Surface coils and head coils that are mounted onto the animal bed are also available with the system. Water beds are integrated in the animal beds to maintain body temperature during anesthesia. Laser crosshairs provide precise positioning of the region of interest. Repositioning accuracy is better than 1 mm.
The new integrated shim and actively shielded gradient system, B-GA 9S, provides extra high-order shim control Z3 and Z4.
Gradient specifications:

  • Outer/inner diameter: 152 mm / 90 mm
  • Gradient strength: 740 mT/m
  • x, y, and z-linearity 60 mm dsv: < 5%
  • Linear inductive rise time (x,y,z): 100 micro-second
  • Slew rate: 6,600 T/m/s

The AVANCE III console provides highest speed RF generation and data acquisition with a highly modular and scalable transmitter and receiver channel architecture. Eight transmitters and eight receivers are available for this MRI scanner. Each receiver provides gating and power for the use of an external preamplifier. The system contains two 1H preamplifiers, one for high power and one for low power RF thresholds, and one preamplifier for X-nuclei.

Softwares

  • The ParaVision 5.1 software package enables acquisition and reconstruction of data sets employing standard MRI techniques as well as user-defined MRI schemes.
  • The ParaVision Spectroscopy Package consisting of TOPSPIN 2.0 for NMR data acquisition, processing, plotting, analysis and simulation as well as MRS techniques, such as localized single voxel spectroscopy and Spectroscopic imaging (CSI).
  • DTI Evaluation Tools can perform calculation of tensor components and scalar invariants (tensor trace, anisotropy index); The DTI Visualization Tools is able to display maps of tensor components , scalar invariants and diffusion direction.

RF Coils

Coils are listed below. Signal to Noise Ratio (SNR) and 90 degree pulse (1 ms pulse width) were measured on mouse/rat brain phantoms.
The abbreviations in the coil name are:
  • Coil type: RES=resonator; SUC=surface coil; ARR=array coil.
  • 500: the 1H system frequency; 1H/13C: the nuclei names for which the coil is tuned.
  • Polarization: LIN=linear; QUAD=quadrature with external combiner; QSN=quadrature south-pole of the magnet at the patient side.
  • Modes: TO=transmit only; RO=receive only; TR=transceiver.
  • AD= the coil is using simple active decoupling; AD2=decoupling of individual saddles.
  • Multi resonant coils: SIM=simultaneous usage possible; SWI=switchable between different nuclei.
CryoProbes:
Bruker's MRI CryoProbe uses cryogenic RF coils and preamplifiers cooled by a closed-cycle refrigeration system. The thermal noise of the RF coil and the associated electronics can be significantly reduced, which increase in sensitivity of a factor of about 2.5 over standard room temperature RF-coils.

Bruker Transceiver Mouse Brain CryoProbe
Coil Name: RF CP F2.5 500 1H M.BR1 Q S TR

Part No. Z111531

Volume Coils:

Bruker Volume Coil
Coil Name: RF RES 500 1H 089/072 QUAD TO AD
Description: Magnet south pole at the user end. Outer diameter is 89 mm, inner diameter is 72 mm.
Part No. T11232V3
SNR:1624 (used as transceiver); 90 degree pulse: 14.0-14.9 db (depend on the surface coils combined)

Bruker PEX Volume Coil
Coil Name: RF ARR 500 1H 089/072 8*1 TO AD
Description: volume coil for Parallel Excitation Unit. Outer diameter is 89 mm, inner diameter is 72 mm.
Part No. T20032V3
SNR:NONE


Bruker Mouse Body Array Volume Coil
Coil Name: RF ARR 500 1H M.BODY 8*1 AD RO
Description: Receive-only 1H mouse body 8 channel coil array, (with integrated preamplifiers, no tune /no match).
Part No. T20033V3
SNR: 7413 (with volume coil T11232V3)


Bruker Rat Body Array Volume Coil
Coil Name: RF ARR 500 1H R.BODY 8*1 AD RO
Description: Receive-only 1H rat body 8 channel coil array, (with integrated preamplifiers, no tune /no match).
Part No. T20035V3
SNR: NONE (with volume coil T11232V3)

Bruker Rat Head/Mouse Body Volume Coil
Coil Name: RF RES 500 1H 075/040 QSN TR
Description: Quadrature 1H resonator for 500 MHz MR systems. Outer diameter is 75 mm, inner diameter is 40mm. Suitable as transceiver or as transmitter for cross coil experiments. It provides the correct circular polarization for the south pole of the magnet being at the patient end. This coil must be used in combination with the rat animal bed T12559.
Part No. T11440V3
SNR: 6404; 90 degree pulse: 27.5 db


Bruker Mouse Head Volume Coil
Coil Name: RF RES 500 1H 023 M.BR QSN TR
Description: Circular Polarized MRI transceiver coil for 1H. Outer diameter 44 mm, inner diameter 23 mm. Distance from front plate to centre is 22 mm, i.e. the black line marked on the surface. This coil must be used in combination with the rat animal bed T12556.
Part No. T12970V3
SNR: 12825 ; 90 degree pulse: 33.2 db

Surface Coils:

Bruker Mouse Brain Surface Coil
Coil Name: RF SUC 500 1H M.BR QSN RO AD
Description: 1H mouse brain receive-only surface coil, circular polarized with integrated combiner and preamplifier, no tune/ no match. It muse be used in combination with an actively detuned transmit-only resonator.
Part No. T11657V3
SNR: 21707 (with T11232V3 volume coil )

Bruker Rat Brain Surface Coil
Coil Name: RF SUC 500 1H RATBR QSN RO AD
Description: 1H rat brain receive-only surface coil, circular polarized with integrated combiner and preamplifier, no tune/ no match. It muse be used in combination with an actively detuned transmit-only resonator.
Part No. T11425V3 SN:0029
SNR:7045 (with T11232V3 volume coil )

Bruker Mouse Brain Surface Coil Array
Coil Name: RF ARR 500 1H M.BR LIN RO AD
Description: 1H mouse brain receive-only coil array (with integrated preamplifiers, no tune / no match). It must be used in combination with an actively detuned transmit-only resonator.
Part No. T11766V3
SNR: 21163 (with T11232V3 volume coil )

Bruker Rat Brain Surface Coil Array
Coil Name: RF ARR 500 1H R.BR LIN RO AD
Description: 1H mouse brain receive-only coil array (with integrated preamplifiers, no tune / no match). It must be used in combination with an actively detuned transmit-only resonator.
Part No. T11473V3 SN: 0010
SNR:9757 (with T11232V3 volume coil )

Bruker Mouse Cardiac Coil Array
Coil Name: RF ARR 500 1H M.HRT RO AD
Description: 1H mouse heat receive-only coil array 2*2 with integrated mouse bed and with integrated preamplifiers, no tune / no match. The coil is designed as RF coil attachment to the mouse animal bed. It must be used in combination with an actively detunned transmit-only resonator.
Part No. T20029V3
SNR: 9515 (with T11232V3 volume coil )

Planar Surface Coils:

Bruker 10mm Planar Surface Coil
Coil Name: RF SUC 500 1H ID=10 LIN RO AD LNA
Description: Proton receive-only linear surface coil with diameter 10 mm. This coil is using simple active decoupling. It muse be used in combination with coil T20014V3.
Part No. T12666 SN:0024
SNR: 25852 (with T11232V3 volume coil )


Bruker 15mm Planar Surface Coil
Coil Name: RF SUC 500 1H ID=15 LIN RO AD
Description: Proton receive-only linear surface coil with diameter 15 mm. This coil is using simple active decoupling. It muse be used in combination with coil T20014V3.
Part No. T120209
SNR: 20547 (with T11232V3 volume coil )

Bruker Low-noise Preamplifier
Coil Name: RF SUC 500 1H LNA AV3
Description: The preamplifier is used for the surface coil T12666/T120209.
Part No. T20014V3

Heteronuclear Coils:

Bruker 1H/31P Transceiver Surface Coil
Coil Name: RF SUF 500 1H/31P ID=10 T/R
Description: heteronuclear, transmit/receive surface coils for 31P, equipped with cable, filters, T/R switch and preamplifier. Inner diameter 10 mm.
Part No. T20039V3
SNR(1H): 8064;90 degree pulse (1H): 21.6 db

Bruker 1H/13C Transceiver Surface Coil
Coil Name: RF SUF 500 1H/13C ID=10 T/R
Description: heteronuclear, transmit/receive surface coils for 13C, equipped with cable, filters, T/R switch and preamplifier. Inner diameter 10 mm.
Part No. T20036V3
SNR(1H): 5690; 90 degree pulse(1H): 19.6 db

Bruker 1H/15N Transceiver Surface Coil
Coil Name: RF SUF 500 1H/15N ID=10 T/R
Description: heteronuclear, transmit/receive surface coils for 15N, equipped with cable, filters, T/R switch and preamplifier. Inner diameter 10 mm.
Part No. T20037V3
SNR(1H):5569;90 degree pulse(1H):18.65

Bruker 1H/17O Transceiver Surface Coil
Coil Name: RF SUF 500 1H/17O ID=10 T/R
Description: heteronuclear, transmit/receive surface coils for 17O, equipped with cable, filters, T/R switch and preamplifier. Inner diameter 10 mm.
Part No. T20038V3
SNR(1H):6418; 90 degree pulse(1H): 22.22