Technology Research & Development #2
Quantitative Multi-Modality MRI at 3T and 7T
Principal Investigator: Peter van Zijl, PhD
The discovery of tissue biomarkers that can provide early and more specific
information regarding physiological or metabolic changes can be seen as the
holy grail of clinical imaging. The availability of such biomarkers is one
of the main issues that we are continuously being inquired about by our
driving biomedical projects, which study such topics as pediatric brain
development, cerebral palsy (CP), X-linked adrenoleukodystrophy (X-ALD),
Alzheimer's Disease (AD), Multiple Sclerosis (MS), Huntington's Disease (HD),
and brain tumors. Our overall goal is therefore to develop MRI methodologies
at 3T and 7T that can provide the quantitative biomarkers needed by our DBPs.
Examples of these are magnetization transfer constants (both exchange transfer
and cross-relaxation based), magnetic susceptibility constants derived from
frequency maps (Figure), and cerebral blood volume.
Some research highlights from TR&D2 are:
Processed phase images from a gradient echo at 7T can produce frequency maps that directly correspond to the local susceptibility of structures.