Driving Biomedical Projects,
Collaborations, and Service

Development of new biomedical research tools is most effective when pursued in the context of challenging problems that drive the technology forward. The developments in our technical research and development (TR&D) projects are stimulated by close interaction with ten Driving Biomedical Projects (DBP) in which we work jointly with expert biomedical investigators outside the Resource. In our function as a National Resource, we also make available our instrumentation, software, methods, and expertise to as many biomedical and clinical researchers as possible. Collaboration (more active involvement) and Service (making available expertise and tools that we developed) are therefore key elements of the Resource.

Driving Biomedical Projects
Collaborations and Service Projects
Become a Collaborator

Some imaging methods developed by this resource. From top left, clockwise: visual maps, brain fiber tracking, DTI of spinal cord injury, susceptibility-weighted image of multiple sclerosis, spectroscopy, gyral segmentation.

Driving Biomedical Projects

Below is a list of the primary investigators for the biomedical projects driven by this resource.

List of Projects

DBP	Principal Investigator(s)	Institution	Project Title
1	Linda Chang, MD	University of Hawaii	Pediatric Brain Development
2	Laurie Cutting, PhD	Vanderbilt University	Reading Disability
3	Diane Damiano, PhD Alec Hoon, MD	National Institutes of Health Kennedy Krieger Institute	Cerebral Palsy (CP)
4	Gerald Raymond, MD	Kennedy Krieger Institute	Biomarkers for X-ALD (Adrenoleukodystrophy)
5	Stewart Mostofsky, PhD	Kennedy Krieger Institute	Attention Deficit Hyperactivity Disorder (ADHD)
6	Michael Weiner, MD Marilyn Albert, PhD	N. Califor. Institute for Research & Education Johns Hopkins University	Biomarkers for Alzheimer's Disease (AD)
7	Peter Calabresi, MD	Johns Hopkins University	Biomarkers for Multiple Sclerosis (MS)
8	John Csernansky, MD	Northwestern University	Schizophrenia and Its Progression
9	Stuart Grossman, MD John Laterra, MD, PhD	Johns Hopkins University	Brain Tumor Consortium; Diagnosis & Prognosis
10	Chris Ross, MD, PhD	Johns Hopkins University	Biomarkers for Huntington's Disease (HD)

Collaborations and Service Projects

Key elements of the resource include Collaboration and Service, with both active involvement of our personnel, as well as making our expertise and tools available for the scientific community. Some of these projects are listed below. Due to the wide propagation of our resources, it is not feasible to provide a comprehensive listing; for example, MRIStudio software alone has been disseminated to more than 4000 investigators.

Examples of Some Collaboration (C) and Service (S) Projects

Note: Service pertains to investigators who use our methods or data but do not have a resource investigator as a collaborator.

CS	Principal Investigator(s)	Institution	Project Title
1	Kelly Botteron, MD(C)	Washington University	Major Depressive Disorder and ADHD in Children
2	Argye Hillis, MD (C,S)	Johns Hopkins University	Neuroimaging of Acute Stroke
3	Sakkubai Naidu, MD (C) Dan Ford, MD, MPH	Kennedy Krieger Institute Johns Hopkins University	Pathogenesis of Rett Syndrome
4	Craig Stark, PhD (C)	University of California Irvine	Medial Temporal Lobe Memory System
5	John McDonald III, MD (C)	Kennedy Krieger Institute	Spinal Cord Injury
6	Godfrey Pearlson, MD (C)	Hartford Hospital & Yale University	Quantitative Neuroimaging in Psychosis
7	Craig Malloy, MD (C) Dean Sherry, PhD (C)	University of Texas Southwestern	Southwestern NMR Center for in vivo Metabolism
8	Ned Sacktor, MD (C) Margaret Lentz, PhD	Johns Hopkins University Massachusetts General Hospital	Oxidative Stress Markers and HIV Dementia
9	Carl-Frederick Westin, PhD Ron Kikinis, MD (S)	Brigham and Women's Hospital	White Matter Architecture from Diffusion MRI
10	Christian Beaulieu, PhD (S)	University of Alberta	DTI of Brain and Brain Disease

Become a Collaborator

If you are interested in becoming a collaborator, your application will be evaluated by the Resource Executive Committee. In order to be considered, please submit a completed application form:

http://mri.kennedykrieger.org/nationalresource/collaborate.html