F. M. Kirby Research Center for Functional Brain Imaging
At the Kennedy Krieger Institute

Jeff W.M. Bulte, PhD

Director of Cellular Imaging
Institute for Cell Engineering
Professor
Departments of Radiology, Biomedical Engineering, and Chemical & Biomolecular Engineering, Johns Hopkins University
Affiliated Faculty
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute
Jeff Bulte, PhD

The Director of the Cellular Imaging Section for JHU's Institute for Cellular Engineering, Dr. Jeff Bulte.

Biographical Sketch

Dr. Bulte completed his undergraduate and masters degrees in Biology and Medical Biology, respectively, from the Free University of Amsterdam in The Netherlands. He received his PhD in Medicine summa cum laude from the University of Groningen in The Netherlands in 1991. Afterwards, he joined the National Institutes of Health in Bethesda, MD, where he completed a fellowship, then became a staff scientist. He was then recruited to become a professor in several departments at the Johns Hopkins University, including Radiology, Chemical & Biomolecular Engineering, and Biomedical Engineering. Currently, Dr. Bulte serves as the Director of the Cellular Imaging Section for the JHU Institute for Cell Engineering.

Research Summary

The clinical development of novel immune and stem cell therapies calls for suitable methods that can follow the fate of cells non-invasively in humans at high resolution. The Bulte lab has pioneered methods to label cells magnetically (using tiny superparamagnetic iron oxide nanoparticles) in order to make them visible by MR imaging. Following years of extensive animal research, this technology has recently been introduced in the clinic for dendritic cell cancer vaccines. MRI cell tracking is further pursued in animal models of dysmyelination, multiple sclerosis, brain tumors, spinal cord, stroke, and myocardial infarct. Novel reporter genes are also being developed that can provide contrast on MRI scans. Artificial proteins are being designed, cloned, and expressed in mammalian cells that contain specific proton exchangable groups of which the proton signal can be manipulated. A new direction is not directly labeling cells, but instead labeling semi-permeable microcapsules that offer immunoprotection of cellular therapeutics. The current focus is on encapsulated pancreatic beta cells that can cure diabetes in mice and are being used in a large animal (swine) model. While the lab is doing basic bench-type research, there is a strong interaction with the clinical interventional radiology and oncology groups in order to bring the methodologies into the clinic.

More information can be found on Dr. Bulte's profile on the Johns Hopkins ICE Website: http://www.hopkins-ice.org/vascular/int/bulte.html

Contact Information

Departmental Address
The Johns Hopkins University School of Medicine
Russell H. Morgan Department of Radiology and Radiological Science
Division of MR Research
217 Traylor Bldg, 720 Rutland Ave
Baltimore, MD 21205

Phone: 443-287-0996 or 410-614-2733
Fax: 443-287-7945
Email: jwmbulte at mri dot jhu dot edu

Assistant: Cindy Atkinson (catkins6 at jhmi dot edu), 410-955-4247

Curriculum Vitae

  • Current Appointments
    • Professor, Department of Radiology
      2006 to Present
      Associate Professor, Department of Radiology: 2002 - 2006
      Assistant Professor, Department of Radiology: 2001 - 2002
      The Johns Hopkins University School of Medicine, Baltimore, MD
    • Professor, Department of Chemical & Biomolecular Engineering
      2007 to Present
      The Johns Hopkins University Whiting School of Engineering, Baltimore, MD
    • Professor, Department of Biomedical Engineering
      2007 to Present
      The Johns Hopkins University Whiting School of Engineering, Baltimore, MD
    • Director, Cellular Imaging Section
      2006 to Present
      JHU Institute for Cell Engineering
      The Johns Hopkins University School of Medicine, Baltimore, MD
  • Awards and Achievements
    • Fellow, ISMRM
      2008, International Society for Magnetic Resonance in Medicine
    • Semi-Finalist, HHMI Investigator Tri-Annual Open Competition
      2008
    • Top-Cited Paper and Annual Front Cover of NMR in Biomedicine
      2007
    • First Place, Annual Citation Award
      2005, 2007, Division of MR Research, Department of Radiology, Johns Hopkins University
    • Thomson ISI Top 1% Citation Certificate of Merit
      2005
    • PhD Degree con judicium "summa cum laude" (>95% percentile)
      1991
  • Education and Training
    • PhD, Medicine
      1991
      University of Groningen, The Netherlands
    • MS, Medical Biology
      1987
      Free University of Amsterdam, The Netherlands
    • BS, Biology
      1983
      Free University of Amsterdam, The Netherlands
  • Professional Experience
    • Staff Scientist (Title 42 USC), Laboratory of Diagnostic Radiology Research (CC)
      1996 - 2001
      National Institutes of Health, Bethesda, MD
    • Postdoctoral Fellow, Laboratory of Diagnostic Radiology Research
      1992 - 1995
      National Institutes of Health, Bethesda, MD
    • Researcher, KWF (Dutch Cancer Society)
      1987 - 1991
      University of Groningen, The Netherlands
  • Affiliations
    • Study Sections: NIH, DOE, NAS, NMSS, CIRM (permanent scientific charter member)
    • Editorial Board: Magnetic Resonance in Medicine (MRM), Current Topics in Stem Cell Research, Nanomedicine, Contrast Media and Molecular Imaging (CMMI), Molecular Imaging, Journal of Magnetic Resonance Imaging (JMRI)
    • Council Member: Society for Molecular Imaging (2004 - 2006)
    • Chair: ISMRM Molecular and Cellular Imaging Study Group (2006 - 2007)
    • Annual Meeting Program Council (AMPC): ISMRM (2008 - 2011)

Publications

For a list of Dr. Bulte's most recent publications searched from the NIH's PubMed Database, please use this Search Link or to the frame below.