Dr. Hanzhang Lu obtained his BS degree from Shanghai Jiao Tong University, China (1996) and his Master's (1999) and PhD (2004) degrees from the Johns Hopkins University, all in Biomedical Engineering. He received his postdoctoral training at the Center for Biomedical Imaging, New York University Medical Center. He was on the faculty of UT Southwestern Medical Center from 2005 to 2014. In 2015, he joined the faculty of Johns Hopkins University (JHU) School of Medicine. Currently, he is an Associate Professor in the Department of Radiology at JHU. Dr. Lu's research is focused on the development of novel MRI techniques to evaluate the brain's vascular physiology and metabolism, as well as their clinical applications. Dr. Lu is on the editorial boards of Neuroimage and NMR in Biomedicine, and serves as a charter member of NIH's Medical Imaging (MEDI) Study Section.
Dr. Lu's research is focused on the development of MRI techniques to understand brain physiology and pathophysiology. He has previously developed MRI pulse sequences to measure cerebral blood volume (CBV) and cerebral blood flow (CBF), for both resting-state measurements and task-evoked changes. His more recent work involves the development of a novel pulse sequence, T2-Relaxation-Under-Spin-Tagging (TRUST) MRI, to measure brain venous oxygenation and cerebral metabolic rate of oxygen (CMRO2) in humans without using exogenous contrast agent. He has conducted a multi-site trial of the TRUST technique to demonstrate its portability and reproducibility. Working with collaborators, he has demonstrated its clinical utility in Multiple Sclerosis, Alzheimer's disease, aging, neonates, anorexia, glucose transporter deficiency, sickle cell anemia, and cocaine addiction. Dr. Lu also has strong interest in the use of gas challenges such as CO2 and O2 inhalation to probe brain physiology. Over the past few years, his laboratory has made meaningful contributions to this rapidly growing field. His group has published an important paper reporting a neural suppression effect of CO2 on the brain, by using both MRI and EEG modalities. He has also conducted substantial work on optimizing imaging techniques to map cerebrovascular reserve with gas challenge, including breathing apparatus, inhalation paradigm, image acquisition protocol, and data analysis strategies. The goal of this line of work is to enable gas-inhalation MRI in routine clinical examinations. Dr. Lu's research has been funded by NIBIB, NIMH, NINDS, and NIA.